Genetic algorithms and macromolecular phasing
نویسندگان
چکیده
منابع مشابه
Macromolecular Phasing
© 2006 American Institute of Physics, S-0031-9228-0603-030-4 M molecular biophysics is built on the twin pillars of genetic engineering and macromolecular structure determination. And x-ray crystallography is foremost among the methods used to determine the atomic-scale structure of macromolecules—very large molecules with sizes typically ranging from 50 to 1000 Å. X-ray crystallography played ...
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In this report we show for the first time that neutron anomalous dispersion can be used in a practical manner to determine experimental phases of a protein crystal structure, providing a new tool for structural biologists. The approach is demonstrated through the use of a state-of-the-art monochromatic neutron diffractometer at the Institut Laue-Langevin (ILL) in combination with crystals of pe...
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A haplotype is the sequence of nucleotides along a single chromosome. As humans, we have 23 pairs of chromosomes. However, with current technology, it is di cult to separate the two chromosomes of a pair and we often get combined haplotype, or genotype, information. The objective of haplotype phasing is to resolve (phase) the haplotypes given genotype information. Knowing the haplotypes not onl...
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Central to crystallographic structure solution is obtaining accurate phases in order to build a molecular model, ultimately followed by refinement of that model to optimize its fit to the experimental diffraction data and prior chemical knowledge. Recent advances in phasing and model refinement and validation algorithms make it possible to arrive at better electron density maps and more accurat...
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Ab initio phasing of macromolecular structures, from the native intensities alone with no experimental phase information or previous particular structural knowledge, has been the object of a long quest, limited by two main barriers: structure size and resolution of the data. Current approaches to extend the scope of ab initio phasing include use of the Patterson function, density modification a...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 1996
ISSN: 0108-7673
DOI: 10.1107/s0108767396096493